"I'm excited about the big event that we're in," said participant Arther Smith.
"A lot of people are coming to see us. I'm so happy for this Saturday."
Seventy-five athletes and more than 200 volunteers will participate in soccer and basketball events at the University of Southern Mississippi.
"I've been working on my layups and three pointers," Smith said.
"I hope we can win the first round to the second round," said Kyndell Moore.
Coaches worked with athletes for six weeks and coordinators said a lot has gone into making the competition possible.
"Community business partners have donated snacks, and we've had many individual ones to make generous donations," said Allison Hinz, assistant director of the Hub City Region.
"This is just a great chance for our community and our athletes with intellectual disabilities to experience, fun, excitement and meet new people."
Participants said they have what it takes to win the Hub City games and advance to the second round in Jackson on April 2.
Opening ceremonies start at 9 a.m. on Saturday at the intramural fields at Southern Miss.