Southern Miss earned their first victory in Hattiesburg since 2011, with a 26-20 win against Alcorn State.
Sophomore quarterback Nick Mullens finished the night 21/33 for 208 yards and two touchdowns.
True freshman Ito Smith carried the ball 32 times for 118 yards with his longest run going for 19.
The Golden Eagles defense forced 4 turnovers including the game-clinching 4th quarter interception from redshirt freshman Jomez Applewhite.
USM travels to face the Alabama Crimson Tide next week.